Neurology

Carotid Ultrasound

Carotid ultrasound is a valuable tool for measuring and tracking carotid plaque area over time. Dr. Spence outlines how 3D ultrasound methods are used to calculate plaque area, which is an important predictor of stroke, myocardial infarction and death, and to follow plaque progression or regression, which are critical treatment targets. Using this novel approach, Dr. Spence et al. have found that a change in therapeutic strategies, targeting the arteries and not LDL levels, has led to less disease progression in their test population despite a rise in mean patient age.
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Carotid MR Imaging

Exploring the characteristics of vulnerable plaque is pivitol to the understanding of atherosclerosis disease progression. Traditionally, this has been done through histology, allowing for risk categories to be created. Dr. Moody et al., are using MR imaging (and PET imaging through CAIN2) to investigate tissue character, which, when related to histology, may be used to predict future events. It is anticipated that this knowledge could then be used for screening, for future long term trials, and to predict disease progression in the brain.
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Ultrasound Techniques for Carotid Imaging: 3D Ultrasound

Using specialized equipment and advanced software, Dr. Fenster et al. have extended 2 dimensional ultrasound images to 3 dimensional acquisition. Through further software development, it has been possible for his team to reconstruct and measure existing carotid plaque in real time, allowing for accurate mapping of plaque regression or progression over time. Looking forward, Dr. Fenster describes current programs attempting to semi-automate plaque tracing on images.
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Carotid Ultrasound +

Carotid ultrasound is a valuable tool for measuring and tracking carotid plaque area over time. Dr. Spence outlines how 3D… Read More
Molecular Imaging Probes: Discovery, Development and Manufacturing +

Taking novel imaging probes from discovery in a lab setting, through full development and on to manufacturing and clinical trials… Read More
Validation of Preop Imaging in Carotid Endarterectomy Specimens +

Working within the goal of CAIN2, Dr. Spence outlines the importance and methods towards outlining atherosclerosis patients would would benefit… Read More
High Resolution MRI and Predicting Ischemic Brain Lesions: CAIN1 +

The ability to anticipate future ischemic events in the brain is the goal of CAIN1. This presentation given by Josephine… Read More
Cerebrovascular Consequences of Atherosclerosis +

Atherosclerosis is not a disease that happens in isolation and can often lead to Small Vessel Disease and other serious… Read More