• Translational Imaging of Coronary Vascular Reactivity with Myocardial Perfusion PET

    The effects of coronary artery diseases on the macrovasculature of the heart have been extensively studied, in contrast to the limited knowledge of effects seen in the microvasculature. As symtoms in the small vessels are an early warning sign of coronary artery disease, slowing or halting progression of these symptoms through improved diagnosis is the aim of the presented research. Dr. Robert deKemp is adapting PET imaging's stress over rest flow reserve, an established method in evaluating macrovasculature, to study the microvasculature. He presents his lab's translational micro-PET evalutaion of mice to determine effects of various stressors to eventually improve diagnostic procedures in humans and pre-clinically evaluate new therepeutic drugs. Read More
  • Carotid Ultrasound

    Carotid Ultrasound

    Carotid ultrasound is a valuable tool for measuring and tracking carotid plaque area over time. Dr. Spence outlines how 3D ultrasound methods are used to calculate plaque area, which is an important predictor of stroke, myocardial infarction and death, and to follow plaque progression or regression, which are critical treatment targets. Using this novel approach, Dr. Spence et al. have found that a change in therapeutic strategies, targeting the arteries and not LDL levels, has led to less disease progression in their test population despite a rise in mean patient age. Read More
  • Ultrasound Techniques for Carotid Imaging: 3D Ultrasound

    Ultrasound Techniques for Carotid Imaging: 3D Ultrasound

    Using specialized equipment and advanced software, Dr. Fenster et al. have extended 2 dimensional ultrasound images to 3 dimensional acquisition. Through further software development, it has been possible for his team to reconstruct and measure existing carotid plaque in real time, allowing for accurate mapping of plaque regression or progression over time. Looking forward, Dr. Fenster describes current programs attempting to semi-automate plaque tracing on images. Read More
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  • Carotid Ultrasound +

    Carotid Ultrasound Carotid ultrasound is a valuable tool for measuring and tracking carotid plaque area over time. Dr. Spence outlines how 3D… Read More

  • Cardiac and Vascular Imaging +

    Cardiac and Vascular Imaging Understanding the markers of atherosclerosis is pivitol to providing effective care and perhaps prevention of the disease in others. Currently,… Read More

  • Validation of Preop Imaging in Carotid Endarterectomy Specimens +

    Validation of Preop Imaging in Carotid Endarterectomy Specimens Working within the goal of CAIN2, Dr. Spence outlines the importance and methods towards outlining atherosclerosis patients would would benefit… Read More

  • Myocardial Perfusion Imaging and Flow Quantification with Rubidium-82 PET +

    Myocardial Perfusion Imaging and Flow Quantification with Rubidium-82 PET Responding to the impending shut down of reactor facilities and a call for further research, deKemp et al. are exploring… Read More

  • Translational Imaging of Coronary Vascular Reactivity with Myocardial Perfusion PET +

    The effects of coronary artery diseases on the macrovasculature of the heart have been extensively studied, in contrast to the… Read More
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