Translational Imaging of Coronary Vascular Reactivity with Myocardial Perfusion PET

The effects of coronary artery diseases on the macrovasculature of the heart have been extensively studied, in contrast to the limited knowledge of effects seen in the microvasculature. As symtoms in the small vessels are an early warning sign of coronary artery disease, slowing or halting progression of these symptoms through improved diagnosis is the aim of the presented research. Dr. Robert deKemp is adapting PET imaging's stress over rest flow reserve, an established method in evaluating macrovasculature, to study the microvasculature. He presents his lab's translational micro-PET evalutaion of mice to determine effects of various stressors to eventually improve diagnostic procedures in humans and pre-clinically evaluate new therepeutic drugs.