Responding to the impending shut down of reactor facilities and a call for further research, deKemp et al. are exploring alternative agents for PET imaging of the heart that do not rely on Technetium-99m. In finding a suitable alternative, Rubidium-82 has been investigated for its accuracy and binding affinity, its ability to provide a prognosis of future events, and ability to guide effective therapy. Dr. deKemp provides an overview of the work completed to date, together with future directions of this research.